You will find a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to lessen afferent soreness transmission and produce analgesia. Therefore, medicine like clonidine that concentrate on alpha-2 receptors can influence the transmission of pain. Relates to clonidine: oral tablet, https://www.proleviate.com/post/the-new-pain-killer-conolidine